Talacotuzumab Biosimilar (IL-3Ra / CD123 Reference Antibody）

SKU: orb2703880

描述

Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models.

研究领域

Immunology & Inflammation

图片与验证

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关键属性

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抗体类型	Biosimilar Antibody
克隆性	Monoclonal
靶点	Talacotuzumab Biosimilar（Anti-IL-3Ra / CD123 Reference Antibody）
纯度	>98%
偶联	Unconjugated

储存与操作

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储存	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
有效期	12 months from date of receipt.
免责声明	For research use only

质量保证

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常用数据库链接

基因符号

Talacotuzumab Biosimilar（Anti-IL-3Ra / CD123 Reference Antibody）

实验方案信息

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