TIM3 Antibody / HAVCR2

SKU: orb607157

描述

TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4+Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.

研究领域

Immunology & Inflammation

图片与验证

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已测应用	ELISA, IHC-P
稀释范围	ELISA: order BSA/sodium azide-free format for coating,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
反应性	Human
应用说明	Optimal dilution of the TIM3 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

关键属性

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抗体类型	Primary Antibody
宿主	Mouse
克隆性	Monoclonal
同种型	Mouse IgG2a, kappa
克隆号	TIM3/3113
免疫原	A recombinant fragment of human TIM3 protein within amino acids 22-202 was used as the immunogen for the TIM3 antibody.
纯化	Protein G affinity chromatography
偶联	Unconjugated

储存与操作

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储存	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
缓冲液/防腐剂	0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
有效期	12 months from date of receipt.
免责声明	For research use only

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TIM3 Antibody / HAVCR2 [orb699596]
应用：
IHC-P, WB
反应性：
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种属/宿主：
Mouse
克隆性：
Monoclonal
偶联：
Unconjugated
可选规格： 100 μg, 20 μg
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TIM3 Antibody / HAVCR2 [orb2642903]
应用：
ELISA, IHC-P
反应性：
Human
种属/宿主：
Mouse
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偶联：
Unconjugated
可选规格： 100 μg
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TIM3 Antibody / HAVCR2 [orb2644454]
应用：
IHC-P, WB
反应性：
Human
种属/宿主：
Mouse
克隆性：
Monoclonal
偶联：
Unconjugated
可选规格： 100 μg
Item 1 of 4
TIM3 Antibody / HAVCR2 [orb699820]
应用：
IHC-P, WB
反应性：
Human
种属/宿主：
Mouse
克隆性：
Monoclonal
偶联：
Unconjugated
可选规格： 100 μg, 20 μg
Item 1 of 4
TIM3 Antibody / HAVCR2 [orb2644902]
应用：
IHC-P, WB
反应性：
Human
种属/宿主：
Mouse
克隆性：
Monoclonal
偶联：
Unconjugated
可选规格： 100 μg

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

常用数据库链接

UniProt

Q8TDQ0

UniProt 详情

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暂无 UniProt 数据

实验方案信息

IHC-P

石蜡切片免疫组化

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ELISA

酶联免疫吸附测定（ELISA）

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可选规格

请在下方选择规格

20 μg

¥ 4,810.00

100 μg

¥ 9,750.00

选择偶联或无载体版本

免费二抗（20 µl）0/0

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数量

Usually dispatched within 5-10 working days

批量询价

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