Verteporfin

SKU: orb1304525

特色

描述

Verteporfin is a clinically used photosensitizer and a small molecule inhibitor of the YAP-TEAD protein interaction, a key pathway in the Hippo signaling cascade. It has been widely utilized in research to study oncogenesis, fibrosis, and regenerative processes, demonstrating effects on apoptosis and autophagy in both cellular and animal models.

研究领域

Cardiovascular Research, Cell Biology, Stem Cell & Developmental Biology

图片与验证

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关键属性

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CAS 号	129497-78-5
MW	718.8
纯度	>98%
分子式	C₄₁H₄₂N₄O₈
SMILES	COC(=O)CCc1c(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CCC(O)=O)c5C)[C@]1(C)[C@H](C(=O)OC)C(=CC=C41)C(=O)OC)c(C)c3C=C
靶点	Transcription factor
溶解性	Soluble in DMSO (up to 14 mg/ml)

生物活性

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靶点 IC50	OMM1 cells:5.89 μM\|Mel 270 cells:6.43 μM\|Omm 2.3 cells:7.27 μM
体内	Verteporfin forms a complex with LDL, which may be taken up by proliferating cells (e.g., neovascular endothelial cells) through LDL receptors or endocytosis. The therapy with Verteporfin achieves complete vascular occlusion through thrombosis in the vascular channels following selective endothelial damage. As shown by optical and electron microscopy, Verteporfin therapy selectively induces occlusion in regenerating and detached choroidal capillaries, without altering the overlying photoreceptors or ganglion cells. Verteporfin rapidly exhibits apoptotic changes in conjunction with light, as demonstrated by the activation of caspase-3 and caspase-9 and the cleavage of PARP in HL-60 cells, changes that are inhibited by the broad-spectrum caspase inhibitor ZVAD.fmk.
体外	Verteporfin metabolizes into a less active form within the body and is rapidly cleared, primarily excreted via feces and to a lesser extent through urine. Its therapy is effective and selectively prevents fluorescein dye leakage from choroidal neovascularization (CNV) induced in experimental monkeys. Verteporfin quickly accumulates in the choroidal vasculature, retinal pigment epithelium (RPE), and photoreceptors of established rabbit eyes. Upon intravenous injection in mice, peak tissue levels of Verteporfin are reached within 3 hours, followed by a rapid decline within 24 hours.
细胞研究	Verteporfin is dissolved in DMSO. PDX cells co-cultured with S17 cells are treated with 16 combinations of verteporfin (60 nM, 120 nM, 180 nM, and 240 nM) and dasatinib (12 nM, 24 nM, 36 nM, and 48 nM). The viabilities of cells treated with each combination are measured after 48 h using FACS Aria flow cytometer. In order to estimate drug interaction between verteporfin and dasatinib, a normalized isobologram and fraction affectedcombination index (CI) plot are made using CompuSyn software. CI values greater than 1.0 indicated antagonistic effects, equal to 1.0 additive effects, and below 1.0 synergistic effects.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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CL 318,952; BPD-MA

相似产品

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Ahx-CES [orb3142690]
可选规格： 50 mg, 10 mg
MACTIDE-V [orb3023008]
可选规格： 10 mg, 50 mg
Verteporfin [orb1226601]
纯度：
>98% (HPLC)
CAS 号：
129497-78-5
MW:
718.79
分子式：
C₄₁H₄₂N₄O₈
可选规格： 2 mg, 5 mg, 10 mg, 25 mg, 100 mg, 50 mg, 200 mg, 500 mg, 1 g

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

化合物标识

PubChem CID

91181808 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

纯度：	>98% (HPLC)
CAS 号：	129497-78-5
MW:	718.79
分子式：	C₄₁H₄₂N₄O₈

Verteporfin

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

Ahx-CES [orb3142690]

MACTIDE-V [orb3023008]

Verteporfin [orb1226601]

质量保证

化合物标识

关键属性

实验方案信息

可选规格