XH-04

SKU: orb3033137

描述

XH-04 (Lipid#4) is an ionizable lipid engineered for advanced mRNA delivery developed by JiaChen West Lake Biotech. Its core structure features a central benzene ring with asymmetric hydrophobic tails (C9-C10 chains) and pH-responsive tertiary amines that enable efficient mRNA encapsulation and endosomal escape. As detailed in CN113993839A, XH04 outperforms industry benchmarks (e.g., MC3 lipid), boosting protein expression by >10-fold in BHK cells. In PCT/CN2024/121624, JiaChen further demonstrated its utility in lung-targeted LNPs (tLNP/tLCNP). When combined with cationic lipids (e.g., DOTMA at 2:1 molar ratio), XH 04 redirects >80% of mRNA delivery to murine lungs—overcoming liver tropism—while maintaining low toxicity. The lipid’s benzenic core and optimized alkyl chain geometry (patent claims 1-9) are credited for enhanced endosomal disruption and mRNA release kinetics. JiaChen’s innovations position XH-04 as a cornerstone for next-generation mRNA therapeutics.

图片与验证

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关键属性

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MW	790.18
纯度	>95%
分子式	C₄₇H₈₃O₈N
SMILES	CCCCCCCCCOC(=O)CCCCCCCOC1=CC(COC(=O)CCCN(C)C)=C(OCCCCCCCC(=O)OCCCCCCCCC)C=C1

储存与操作

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有效期	12 months from date of receipt.
免责声明	For research use only

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实验方案信息

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