Y-27632 dihydrochloride

SKU: orb1226595

描述

Y-27632 2hydrochloride is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.(In Vitro):Y-27632 (1-5 μM; 0-60 min) promotes neuronal differentiation of adipose tissue-derived stem cells (ADSCs) .Y-27632 (1-5 μM; 0-60 min) induces the expression of NSE, MAP-2 and nestin in ADSCs .(In Vivo):Y-27632 (oral gavage; 30 mg/kg; once daily; 4 w) prevents dimethylnitrosamine-induced hepatic fibrosis in rats.Y-27632 (oral gavage; 5-10 mg/kg; once) shows antiepileptic effects in epilepsy induced by PTZ and MES.

图片与验证

−

关键属性

−

CAS 号	129830-38-2
MW	320.26
纯度	>98% (HPLC)
分子式	C₁₄H₂₁N₃O·2HCl
SMILES	C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl
靶点	ROCK
溶解性	Water: 14 mg/mL (43.71 mM); DMSO: 64 mg/mL warmed (199.83 mM)

储存与操作

−

储存	Storage temperature: -20°C. Stability: ≥ 2 years
有效期	12 months from date of receipt.
免责声明	For research use only

相似产品

−

Y-27632 dihydrochloride [orb1307611]
纯度：
99.98% (May vary between batches)
CAS 号：
129830-38-2
MW:
320.26
分子式：
C₁₄H₂₁N₃O·2HCl
可选规格： 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 1g
Item 1 of 1
Y 27632 [orb1713678]
纯度：
≥98% (HPLC)
CAS 号：
146986-50-7
MW:
320.3
分子式：
C₁₄H₂₃Cl₂N₃O
可选规格： 1 mg, 5 mg
Y-33075 dihydrochloride [orb1219732]
纯度：
>98% (HPLC)
CAS 号：
173897-44-4
MW:
353.25
分子式：
C₁₆H₁₈Cl₂N₄O
可选规格： 2 mg, 5 mg, 10 mg, 50 mg, 100 mg, 25 mg, 200 mg, 500 mg, 1 g

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

常用数据库链接

基因符号

ROCK

实验方案信息

查看更多实验方案

纯度：	99.98% (May vary between batches)
CAS 号：	129830-38-2
MW:	320.26
分子式：	C₁₄H₂₁N₃O·2HCl

纯度：	≥98% (HPLC)
CAS 号：	146986-50-7
MW:	320.3
分子式：	C₁₄H₂₃Cl₂N₃O

Y-27632 dihydrochloride

描述

图片与验证

关键属性

储存与操作

相似产品