Y-33075 dihydrochloride

SKU: orb1308924

描述

Y-33075 dihydrochloride is a potent and selective ROCK inhibitor with an IC50 of 3.6 nM. This compound is a valuable research tool for investigating Rho-kinase signaling in cellular studies and has been utilized in preclinical models to explore cardiovascular and neurological pathways.

研究领域

Cell Biology, Epigenetics & Chromatin, Neuroscience, Signal Transduction, Stem Cell & Developmental Biology

图片与验证

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关键属性

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CAS 号	173897-44-4
MW	353.25
纯度	99.89% (May vary between batches)
分子式	C₁₆H₁₈Cl₂N₄O
SMILES	Cl.Cl.C[C@@H](N)c1ccc(cc1)C(=O)Nc1ccnc2[nH]ccc12
靶点	ROCK,PKC,CaMK
溶解性	10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.32 mM);H2O:50 mg/mL (141.54 mM);DMSO:100 mg/mL (283.09 mM)

生物活性

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靶点 IC50	CaMK II:810 nM\|PKC:420 nM\|ROCK:3.6 nM
体内	Y-33075 (≥0.01%) significantly lowers intraocular pressure (IOP) at 2 hours after topical administration in rabbits. Y-33075 (0.05%)-treated eyes show significant reduction of IOP between 2 and 7 hours after topical administration in monkeys. Y-33075 (100 μM) increases the regenerating axons of retinal ganglion cells (RGCs) in the eyes of the rats.
体外	Y-33075 (Y-39983) is a potent inhibitor of ROCK with an IC50 of 3.6 nM and exhibits greater inhibitory effects on PKC and CaMKII compared to Y-27632. The IC50 values for PKC are 9.0 μM for Y-27632 and 0.42 μM for Y-33075, while for CaMKII, the IC50s are 26 μM and 0.81 μM, respectively. The IC50s for Y-27632 and Y-33075 for PKC are 82 and 117 times higher than for ROCK, respectively, and for CaMKII, they are 236 and 225 times higher than for ROCK, respectively . Y-33075 (Y-39983, 10 μM) promotes neurite extension in retinal ganglion cells (RGCs) compared to untreated cells , and at 1 μM, it inhibits the histamine-evoked contraction of rabbit ciliary artery segments in Ca2+-free solutions .

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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CaMKII, inhibit, Inhibitor, Y 33075, Y 33075 Dihydrochloride, Y 33075 dihydrochloride, Rho-associated protein kinase, Rho-associated kinase, Rho-kinase, ROK, ROCK, PKC, Y33075 dihydrochloride, Y33075 Dihydrochloride, Y-33075, Y-33075 Dihydrochloride, Y33075

相似产品

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Y-33075 dihydrochloride [orb1219732]
纯度：
>98% (HPLC)
CAS 号：
173897-44-4
MW:
353.25
分子式：
C₁₆H₁₈Cl₂N₄O
可选规格： 2 mg, 5 mg, 10 mg, 50 mg, 100 mg, 25 mg, 200 mg, 500 mg, 1 g

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化合物标识

PubChem CID

20601328 ↗

关键属性

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暂无计算属性。

实验方案信息

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纯度：	>98% (HPLC)
CAS 号：	173897-44-4
MW:	353.25
分子式：	C₁₆H₁₈Cl₂N₄O

Y-33075 dihydrochloride

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

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