YF135

SKU: orb1983026

描述

YF135 is a reversible-covalent KRAS G12C PROTAC that degrades the oncogenic protein via VHL E3 ligase recruitment and proteasomal destruction, leading to reduced phospho-ERK signaling. This bifunctional molecule, derived from MRTX849 and a VHL ligand, is a valuable chemical tool for investigating KRAS-driven cancers in both cellular and animal models.

研究领域

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

图片与验证

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关键属性

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CAS 号	2913177-53-2
MW	1179.86
分子式	C₆₃H₇₅ClN₁₂O₇S
SMILES	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCCN2CCC[C@H]2COc2nc3CN(CCc3c(n2)N2CCN([C@@H](CC#N)C2)C(=O)C(=C\C2CC2)\C#N)c2cccc3cccc(Cl)c23)C(C)(C)C)cc1
靶点	PROTACs,Ras,Kras,ERK

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

相似产品

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KRAS G12C Ligand-Linker Conjugates 1 [orb3136719]
CAS 号：
3033236-98-2
MW:
823.42
分子式：
C₄₅H₅₅ClN₈O₅
可选规格： 50 mg, 10 mg

质量保证

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化合物标识

PubChem CID

163322223 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

CAS 号：	3033236-98-2
MW:	823.42
分子式：	C₄₅H₅₅ClN₈O₅

YF135

描述

研究领域

图片与验证

关键属性

储存与操作

相似产品

KRAS G12C Ligand-Linker Conjugates 1 [orb3136719]

质量保证

化合物标识

关键属性

实验方案信息

可选规格