MYCi975

SKU: orb1709073

描述

MYCi975

研究领域

Cell Biology

图片与验证

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关键属性

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CAS 号	2289691-01-4
MW	561.303
纯度	99.82% (May vary between batches)
分子式	C₂₅H₁₆Cl₂F₆N₂O₂
SMILES	OC1=C(C2=CC(C(F)(F)F)=NN2C)C=CC(OCC3=CC=C(Cl)C=C3)=C1C4=CC=C(Cl)C(C(F)(F)F)=C4
靶点	c-Myc
溶解性	DMSO:247.5 mg/mL (440.94 mM)

生物活性

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体内	The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index. An improved analog, MYCi975 showed better tolerability.
体外	MYCi975 inhibits P493-6, MV411,SK-N-B2 cells viability in an MYC-dependent manner(IC50s of 3.7, 3.9, 6.4 μM, respectively).

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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cMyc, c-Myc, MYC, MYCi975, MYCi-975, NUCC 0200975, NUCC0200975, NUCC-0200975

相似产品

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MYCi975 [orb1219642]
纯度：
>98% (HPLC)
CAS 号：
2289691-01-4
MW:
561.3
分子式：
C₂₅H₁₆Cl₂F₆N₂O₂
可选规格： 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg, 1 g

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

化合物标识

PubChem CID

139600320 ↗

关键属性

−

暂无计算属性。

实验方案信息

查看更多实验方案

纯度：	>98% (HPLC)
CAS 号：	2289691-01-4
MW:	561.3
分子式：	C₂₅H₁₆Cl₂F₆N₂O₂

MYCi975

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

MYCi975 [orb1219642]

质量保证

化合物标识

关键属性

实验方案信息

可选规格