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Pemigatinib

SKU: orb1309272

描述

Pemigatinib is a potent and selective oral inhibitor of fibroblast growth factor receptors, with the highest activity against FGFR1-3. It is used in preclinical and clinical research for studying cancers driven by FGFR alterations, demonstrating efficacy in both cellular assays and animal models.

研究领域

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

图片与验证

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关键属性

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CAS 号1513857-77-6
MW487.5
纯度99.95% (May vary between batches)
分子式C24H27F2N5O4
SMILESO=C(N1CC)N(C2=C(F)C=C(OC)C(OC)=C2F)CC3=C1C4=C(N=C3)NC(CN5CCOCC5)=C4
靶点FGFR
溶解性DMSO:26.58 mg/mL (54.52 mM);10% DMSO+90% Saline:0.1 mg/mL (0.21 mM)

生物活性

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靶点 IC50
FGFR2:0.5 nM|FGFR3:1.2 nM|FGFR4:30 nM|FGFR1:0.4 nM
体外
In cells expressing FGFR2-CLIP1 fusion are sensitive to Pemigatinib (INCB054828; IC50 value of 10.16 nM).

储存与操作

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储存-20°C
有效期12 months from date of receipt.
免责声明For research use only

别名

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cholangiocarcinoma, antineoplastic, FGFR4, FGFR3, FGFR2, FGFR1, Fibroblast growth factor receptor, FGFR, Inhibitor, inhibit, INCB054828, INCB-054828, INCB 054828, Orally, Pemigatinib

相似产品

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  • Pemigatinib (INCB054828) [orb1220252]

    >98% (HPLC)

    1513857-77-6

    487.5

    C??H??F?N?O?

    25 mg, 50 mg, 100 mg, 5 mg, 10 mg, 200 mg, 500 mg, 1 g
质量保证

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

关键属性

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暂无计算属性。

实验方案信息

可选规格

请在下方选择规格

1 mg
¥ 1,170.00
5 mg
¥ 1,820.00
1 ml x 10 mM (in DMSO)
¥ 1,820.00
10 mg
¥ 2,600.00
25 mg
¥ 4,290.00
50 mg
¥ 6,370.00
100 mg
¥ 8,320.00
发货Usually dispatched within 5-10 working days
批量询价