IM156

SKU: orb1298855

特色

描述

IM156 (HL156A; HL271 acetate) is a potent, orally active AMPK activator and oxidative phosphorylation (OXPHOS) inhibitor derived from Metformin. It has demonstrated efficacy in attenuating aging-associated cognitive impairment in animal models and is investigated for research in solid tumors.

研究领域

Cell Biology, Metabolism Research

图片与验证

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关键属性

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CAS 号	1422365-93-2
MW	315.3
纯度	>98%
分子式	C₁₃H₁₆F₃N₅O
SMILES	N(C(NC(=N)N1CCCC1)=N)C2=CC=C(OC(F)(F)F)C=C2
靶点	Kinase
溶解性	Soluble in DMSO (up to 25 mg/ml)

生物活性

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体内

IM156 does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity . IM156 (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety . IM156 markedly attenuates the aging-induced decline in novel object recognition memory and spatial working memory . IM156 markedly increases AMPK activation in the hippocampus of aged mice . Animal Model: C57BL/6J mice (young group/12-16 weeks, old groups/20-22 months) Dosage: 50 mg/kg Administration: Oral administration (drinking water), for 2 months Result: Attenuated age-related cognitive decline.

体外

IM156 (0.31-10 μM) phosphorylates AMPKα1 Thr172 in NIH3T3 mouse fibroblast cells in a dose- and time-dependent manner . IM156 does not affect the expression of key factors involved in glucose homeostasis like glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1) . Western Blot Analysis Cell Line: NIH3T3 cells Concentration: 0.31 μM, 0.62 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM Incubation Time: 4 hours Result: Significantly increased the AMPK phosphorylation rate.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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HL156A

相似产品

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IM-156 (acetate) [orb1693752]
纯度：
90.00% (May vary between batches)
CAS 号：
2043654-54-0
MW:
375.35
分子式：
C₁₅H₂₀F₃N₅O₃
可选规格： 1 mg

质量保证

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化合物标识

PubChem CID

78092899 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

纯度：	90.00% (May vary between batches)
CAS 号：	2043654-54-0
MW:	375.35
分子式：	C₁₅H₂₀F₃N₅O₃

IM156

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

IM-156 (acetate) [orb1693752]

质量保证

化合物标识

关键属性

实验方案信息

可选规格