MK-4827 hydrochloride

SKU: orb1227084

描述

A highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2; inhibits PARP activity with EC50=4 nM in a whole cell assay, and inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10 100 nM range; well tolerated in vivo and demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer.Ovarian Cancer Approved.

图片与验证

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关键属性

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CAS 号	1038915-64-8
MW	356.8492
纯度	>98% (HPLC)
分子式	C₁₉H₂₁ClN₄O
SMILES	C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N.Cl
靶点	PARP
溶解性	10 mM in DMSO

储存与操作

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储存	Storage temperature: -20°C. Stability: ≥ 2 years
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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Niraparib hydrochloride | MK 4827 hydrochloride | MK4827 hydrochloride

相似产品

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Niraparib hydrochloride [orb1304290]
纯度：
99.90% (May vary between batches)
CAS 号：
1038915-64-8
MW:
356.85
分子式：
C₁₉H₂₁ClN₄O
可选规格： 2 mg, 5 mg, 10 mg, 50 mg, 100 mg, 25 mg, 1 ml x 10 mM (in DMSO)

质量保证

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常用数据库链接

基因符号

PARP

实验方案信息

查看更多实验方案

纯度：	99.90% (May vary between batches)
CAS 号：	1038915-64-8
MW:	356.85
分子式：	C₁₉H₂₁ClN₄O