Niraparib hydrochloride

SKU: orb1304290

描述

研究领域

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

图片与验证

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关键属性

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CAS 号	1038915-64-8
MW	356.85
纯度	99.90% (May vary between batches)
分子式	C₁₉H₂₁ClN₄O
SMILES	C(N)(=O)C=1C=2C(=CN(N2)C3=CC=C(C=C3)[C@@H]4CCCNC4)C=CC1.Cl
靶点	Apoptosis,PARP
溶解性	DMSO:50 mg/mL (140.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.6 mM);H2O:180 mg/mL (504.41 mM)

生物活性

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靶点 IC50	PARP3:1300 nM\|PARP2:2.1 nM\|PARP1:3.8nM\|PARP4:330 nM\|tankyrase 1:570 nM
体内	In cell assays, MK-4827 exhibits inhibitory effects on PARP activity (EC50: 4 nM) and suppresses the proliferation of cancer cells carrying BRCA-1/2 mutations (IC50: 10-100 nM). It effectively inhibits PARP-1/2 (IC50: 3.8/2.1 nM) but shows significantly lower selectivity (over 100-fold) against PARP-3, V-PARP, and tankyrase-1 (IC50: 1300/330/570 nM). In MDA-MB-436 human breast adenocarcinoma cells with a BRCA-1 mutation, MK-4827 has a CC50 of 18 nM; in CAPAN-1 human pancreatic cancer cells with a BRCA-2 deficiency, the CC50 is 90 nM. Normal human prostatic and breast epithelial cells exhibit resistance to MK-4827. This indicates that PARP inhibitors like MK-4827 have selective cytotoxicity in cancer cells with BRCA-1/2 mutations, minimizing the impact on surrounding tissue.
体外	MK-4827 significantly enhances the effectiveness of radiation on human tumor xenografts (whether p53 wild-type or p53 mutant), demonstrating good tolerability in vivo. When used alone, it also exhibits efficacy against BRCA-1 deficient xenograft models.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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damage, DNA, breast, anti-tumor, Apoptosis, cancer, bioavailable, lung, PARP2, PARP3, PARP1, PARP, MK 4827, MK 4827 Hydrochloride, MK4827, MK-4827, MK-4827 (hydrochloride), MK4827 Hydrochloride, MK-4827 hydrochloride, MK-4827 Hydrochloride, Niraparib hydrochloride, Niraparib Hydrochloride, Niraparib, orally, ovarian, inhibit, Inhibitor, V-PARP, TANK-1, poly ADP ribose polymerase

相似产品

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MK-4827 hydrochloride [orb1227084]
纯度：
>98% (HPLC)
CAS 号：
1038915-64-8
MW:
356.8492
分子式：
C₁₉H₂₁ClN₄O
可选规格： 10 mg, 5 mg, 25 mg, 50 mg, 2 mg, 100 mg, 200 mg, 500 mg, 1 g

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

化合物标识

PubChem CID

44550597 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

纯度：	>98% (HPLC)
CAS 号：	1038915-64-8
MW:	356.8492
分子式：	C₁₉H₂₁ClN₄O

Niraparib hydrochloride

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

MK-4827 hydrochloride [orb1227084]

质量保证

化合物标识

关键属性

实验方案信息

可选规格