PI-828

SKU: orb1706792

描述

PI-828 is a selective PI3K inhibitor widely employed in biochemical and cell biology research to investigate PI3K signaling pathways. It has been utilized in both in vitro and in vivo studies to explore mechanisms in oncology, metabolism, and stem cell biology, where it promotes mesodermal differentiation.

研究领域

Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

图片与验证

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关键属性

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CAS 号	942289-87-4
MW	322.36
纯度	99.95% (May vary between batches)
分子式	C₁₉H₁₈N₂O₃
SMILES	Nc1ccc(cc1)-c1cccc2c1oc(cc2=O)N1CCOCC1
靶点	Casein Kinase,PI3K
溶解性	DMSO:11.2 mg/mL (34.74 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.1 mM)

生物活性

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靶点 IC50

CK2α2:1.127 μM|CK2:149 nM|p110α:173 nM

体外

PI-828 (0.78-3.12 µM; 48 hours) reduces caspase 3 activation. However, higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis.The sensitivity to PI-828 is a key feature of PI3K-C2β that shows a different sensitivity to this inhibitor compared to class I PI3Ks. Of note, 1 μM PI-828 has no effect on the activity of PI3K-C2β, while it significantly inhibits class I PI3Ks. In particular, a concentration of 10 μM PI-828 completely blocks class I PI3Ks, whereas it has only a partial inhibitory effect on PI3K-C2β

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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CK2α2, CK2, CaseinKinase, Casein Kinase, p110α, LY-294002, 4gamma-NH2, LY294002, LY 294002, 4gamma-NH2, PI 828, PI828, PI-828

相似产品

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PI-828 [orb2901590]
纯度：
>98% (HPLC)
CAS 号：
942289-87-4
MW:
322.36
分子式：
C₁₉H₁₈N₂O₃
可选规格： 10 mg, 25 mg, 50 mg, 2 mg, 5 mg, 100 mg, 500 mg, 1 g

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

化合物标识

PubChem CID

25181195 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

纯度：	>98% (HPLC)
CAS 号：	942289-87-4
MW:	322.36
分子式：	C₁₉H₁₈N₂O₃

PI-828

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

PI-828 [orb2901590]

质量保证

化合物标识

关键属性

实验方案信息

可选规格