PI-828

SKU: orb2901590

描述

PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively.

图片与验证

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关键属性

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CAS 号	942289-87-4
MW	322.36
纯度	>98% (HPLC)
分子式	C₁₉H₁₈N₂O₃
SMILES	Nc1ccc(cc1)-c1cccc2c1oc(cc2=O)N1CCOCC1
靶点	PI3K
溶解性	In Vitro: DMSO : ≥ 12.5 mg/mL (38.78 mM)

生物活性

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体外

PI-828 (0.01-100 μM) exhibits cytotoxic effect on the 4T1 breast cancer cells and 4306 ovarian cancer cells. PI-828 (0.78-3.12 μM; 48 hours) decreases caspase 3 activation; higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis. Cell Viability Assay Cell line: 4T1 breast cancer cells and 4306 ovarian cancer cells. Concentration: 0.01, 0.1, 1, 10 and 100 μM Incubation time: Result: Exhibited cytotoxic effect. Apoptosis Analysis Cell line: Human embryonic carcinoma NCCIT cells. Concentration: 0.78, 1.56, 3.12, 6.25, 12.5 μM Incubation time: 48 hours. Result: Concentrations of ranging from 0.78 to 3.12 μM decreased caspase 3 activation; higher concentrations caused apoptosis.

储存与操作

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储存	Storage temperature: -20°C. Stability: ≥ 2 years
有效期	12 months from date of receipt.
免责声明	For research use only

相似产品

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PI-828 [orb1706792]
纯度：
99.95% (May vary between batches)
CAS 号：
942289-87-4
MW:
322.36
分子式：
C₁₉H₁₈N₂O₃
可选规格： 5 mg, 25 mg, 1 mg, 10 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 200 mg

质量保证

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常用数据库链接

基因符号

PI3K

实验方案信息

查看更多实验方案

纯度：	99.95% (May vary between batches)
CAS 号：	942289-87-4
MW:	322.36
分子式：	C₁₉H₁₈N₂O₃