PRI-724

SKU: orb1685665

描述

PRI-724 is a selective small molecule that disrupts the β-catenin/CBP protein-protein interaction. It is used in cancer research, particularly for studying Wnt/β-catenin signaling pathways, and has been investigated in both in vitro assays and in vivo preclinical models.

研究领域

Signal Transduction, Stem Cell & Developmental Biology

图片与验证

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关键属性

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CAS 号	1422253-38-0
MW	658.64
纯度	99.11% (May vary between batches)
分子式	C₃₃H₃₅N₆O₇P
SMILES	C([C@@H]1N2[C@@](N(C(NCC3=CC=CC=C3)=O)N(C)CC2=O)([C@H](C)N(CC=4C5=C(C=CC4)C=CC=N5)C1=O)[H])C6=CC=C(OP(=O)(O)O)C=C6
靶点	Wnt/beta-catenin
溶解性	DMSO:55 mg/mL (83.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.04 mM);Ethanol:1.8 mg/mL (2.73 mM)

生物活性

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体内

METHODS: HCV transgenic mice were treated with PRI-724 (5, 20 mg/kg, intraperitoneally, once a day, for 6 weeks) intraperitoneally, and the antifibrotic activity of PRI-724 against HCV-induced liver fibrosis was evaluated. RESULTS In HCV transgenic mice, the expression of S100A4, which is controlled by CBP/β-catenin, was increased; this induction was attenuated by the administration of PRI-724, and the HCV-induced increase in hepatic hydroxyproline was also attenuated. Inhibition of CBP/β-catenin by PRI-724 is effective against HCV-induced liver fibrosis. METHODS: HCV transgenic mice were treated with PRI-724 (0.1, 0.3, 1 mg/kg, subcutaneous injection, 6 weeks) to evaluate the anti-fibrotic activity of PRI-724. RESULTS PRI-724 can effectively reduce the area of collagen fibers in the liver in a dose-dependent manner and increase the expression level of Mmp8 mRNA and the number of F4/80, Ly-6C and Gr-1 positive cells.

体外

METHODS: CAL27 and FaDu cells were treated with HS-173, erlotinib, and PRI-724 (0-100 μM, 48 hours), and cell viability was analyzed by resazurin assay. RESULTS The combination of PRI-724 and HS-173 synergistically reduced the viability of FaDu cells; in CAL27 cells, the best inhibitory results were observed with the mixture of PRI-724 and erlotinib.

储存与操作

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储存	-20°C
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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beta-catenin, betacatenin, bcatenin, C-82 prodrug, Foscenvivint, ICG-001 analog, Wnt/betacatenin, Wnt/b-catenin, Wnt, PRI 724, PRI724, PRI-724, Wnt/β-catenin, βcatenin

相似产品

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ICG-001 [orb1305968]
纯度：
>98%
CAS 号：
847591-62-2
MW:
548.63
分子式：
C₃₃H₃₂N₄O₄
可选规格： 25 mg, 5 mg
PRI-724 [orb1223869]
纯度：
>98% (HPLC)
CAS 号：
847591-62-2
MW:
548.63
分子式：
C₃₃H₃₂N₄O₄
可选规格： 5 mg, 25 mg, 100 mg, 500 mg, 1 g, 2 mg, 50 mg, 10 mg
C-82 [orb1940817]
纯度：
>98% (HPLC)
CAS 号：
1422253-37-9
MW:
578.673
分子式：
C₃₃H₃₄N₆O₄
可选规格： 5 mg, 10 mg, 25 mg, 100 mg, 200 mg, 500 mg, 1 g

质量保证

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化合物标识

PubChem CID

71509318 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

纯度：	>98%
CAS 号：	847591-62-2
MW:	548.63
分子式：	C₃₃H₃₂N₄O₄

纯度：	>98% (HPLC)
CAS 号：	847591-62-2
MW:	548.63
分子式：	C₃₃H₃₂N₄O₄

PRI-724

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

ICG-001 [orb1305968]

PRI-724 [orb1223869]

C-82 [orb1940817]

质量保证

化合物标识

关键属性

实验方案信息

可选规格