Ribociclib

SKU: orb1300987

特色

描述

Ribociclib

研究领域

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

图片与验证

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关键属性

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CAS 号	1211441-98-3
MW	434.5
纯度	>98%
分子式	C₂₃H₃₀N₈O
SMILES	C(N(C)C)(=O)C=1N(C=2C(C1)=CN=C(NC3=CC=C(C=N3)N4CCNCC4)N2)C5CCCC5
靶点	Kinase
溶解性	Soluble in DMSO (up to 10 mg/ml)

生物活性

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靶点 IC50	4T1 cells:> 10 μM\|CDK4:10 nM\|HepG2 cells:> 10 μM\|Jurkat cells:> 10 μM\|HCC827 cells:> 10 μM\|MCF-7 cells:> 10 μM\|CCRF-CEM cells:> 10 μM\|CDK6:39 nM\|Hep 3B2 cells:> 10 μM\|A375 cells:> 10 μM\|HeLa cells:> 10 μM\|A549 cells:> 10 μM\|B16 F10 cells:> 10 μM\|BXPC-3 cells:68.37 μM\|MDA-MB-231 cells:> 10 μM
体内	LEE011 inhibits the growth of neuroblastoma cells, a process regulated by G1 cell cycle arrest and cellular senescence. It demonstrates significant growth suppression in 12 out of 17 neuroblastoma types evaluated, with an average IC50 of 307 nM.
体外	LEE011 (200 mg/kg/day, p.o.) significantly delayed the growth of BE2C or 1643 cells in mice without causing weight loss or other toxic symptoms.
细胞研究	A panel of neuroblastoma cell lines, selected based upon prior demonstration of substrate adherent growth, is plated in triplicate on the Xcelligence Real-Time Cell Electronic Sensing system and treated 24 hours later with a four-log dose range of inhibitor or with a dimethyl sulfoxide (DMSO) control. Cell indexes are monitored continuously for ~100 hours, and IC50 values are determined as follows: growth curves are generated by plotting the cell index as a function of time and are normalized to the cell index at the time of treatment for a baseline cell index of 1. The area under the normalized growth curve from the time of treatment to 96 hours posttreatment is then calculated using a baseline area of 1 (the cell index at the time of treatment). Areas are normalized to the DMSO control, and the resulting data are analyzed using a nonlinear log inhibitor versus normalized response function. All experiments are repeated at least once. (Only for Reference)

储存与操作

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储存	RT
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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LEE011

相似产品

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DOTA-RBB-Ga [orb3143103]
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C₃₉H₅₃GaN₁₂O₈
可选规格： 10 mg, 50 mg
Ribociclib impurity 5 [orb3216724]
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775288-71-6
MW:
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C₉H₁₂N₄O₂
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LEQ803 [orb3028678]
CAS 号：
1211441-59-6
MW:
420.511
分子式：
C₂₂H₂₈N₈O
可选规格： 50 mg, 10 mg
LO-3-63 [orb3135894]
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Ribociclib succinate hydrate [orb1707086]
CAS 号：
1374639-79-8
MW:
570.651
分子式：
C₂₇H₃₈N₈O₆
可选规格： 50 mg, 100 mg, 25 mg

质量保证

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化合物标识

PubChem CID

44631912 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

CAS 号：	775288-71-6
MW:	208.22
分子式：	C₉H₁₂N₄O₂

CAS 号：	1211441-59-6
MW:	420.511
分子式：	C₂₂H₂₈N₈O

CAS 号：	1374639-79-8
MW:	570.651
分子式：	C₂₇H₃₈N₈O₆

Ribociclib

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

DOTA-RBB-Ga [orb3143103]

Ribociclib impurity 5 [orb3216724]

LEQ803 [orb3028678]

LO-3-63 [orb3135894]

Ribociclib succinate hydrate [orb1707086]

质量保证

化合物标识

关键属性

实验方案信息

可选规格