Verapamil hydrochloride

SKU: orb1226158

描述

Verapamil Hcl is an L-type calcium channel blocker of the phenylalkylamine class.(In Vitro):The EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells is inhibited by cationic drugs, and inhibits by verapamil in a concentration-dependent manner with an IC50 of 98.0 μM.(In Vivo):Given orally Verapamil is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation.Verapamil is injected i.v. into a femoral vein prior to ischemia. Verapamil (1 mg/kg) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Total arrhythmia scores are significantly increased when the heart is subjected to ischemia. Verapamil (1 mg/kg) significantly prevents the enhancement of total arrhythmia scores induced by ischemia.

研究领域

Pharmacology & Drug Discovery

图片与验证

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关键属性

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CAS 号	152-11-4
MW	491.06
纯度	>98% (HPLC)
分子式	C₂₇H₃₉ClN₂O₄
SMILES	N#CC(C(C)C)(C1=CC=C(OC)C(OC)=C1)CCCN(CCC2=CC=C(OC)C(OC)=C2)C.[H]Cl
靶点	Calcium Channel
溶解性	Ethanol: 12 mg/mL (24.43 mM); Water: 50 mg/mL (101.82 mM); DMSO: 98 mg/mL (199.56 mM)

生物活性

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体内

Given orally Verapamil is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation. Verapamil is injected i. v. into a femoral vein prior to ischemia. Verapamil (1 mg/kg) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Total arrhythmia scores are significantly increased when the heart is subjected to ischemia. Verapamil (1 mg/kg) significantly prevents the enhancement of total arrhythmia scores induced by ischemia.

体外

The EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells is inhibited by cationic drugs, and inhibits by verapamil in a concentration-dependent manner with an IC50 of 98.0 μM.

储存与操作

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储存	Storage temperature: -20°C. Stability: ≥ 2 years
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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NSC 272366 | NSC 657799

相似产品

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(S)-Verapamil hydrochloride [orb1818501]
纯度：
>98%
CAS 号：
36622-28-3
MW:
477.03598
分子式：
C₂₆H₃₇N₂O₄+.CL-
可选规格： 100 mg
Gallopamil hydrochloride [orb3033040]
CAS 号：
16662-46-7
MW:
521.088547468185
分子式：
C₂₈H₄₁CLN₂O₅
可选规格： 100 mg, 250 mg, 1 g
BODIPY FL Verapamil hydrochloride [orb2566798]
可选规格： 50 mg, 10 mg
Gallopamil hydrochloride [orb1309645]
纯度：
99.86% (May vary between batches)
CAS 号：
16662-46-7
MW:
521.09
分子式：
C₂₈H₄₁ClN₂O₅
可选规格： 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg, 1 mg, 1 ml x 10 mM (in DMSO)
Verapamil HCl [orb1310060]
纯度：
>98%
CAS 号：
152-11-4
MW:
491.06
分子式：
C₂₇H₃₈N₂O₄ ∙ HCl
可选规格： 1 g, 5 g

质量保证

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常用数据库链接

基因符号

Calcium Channel

实验方案信息

查看更多实验方案

纯度：	>98%
CAS 号：	36622-28-3
MW:	477.03598
分子式：	C₂₆H₃₇N₂O₄+.CL-

CAS 号：	16662-46-7
MW:	521.088547468185
分子式：	C₂₈H₄₁CLN₂O₅

纯度：	99.86% (May vary between batches)
CAS 号：	16662-46-7
MW:	521.09
分子式：	C₂₈H₄₁ClN₂O₅

Verapamil hydrochloride

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

(S)-Verapamil hydrochloride [orb1818501]

Gallopamil hydrochloride [orb3033040]

BODIPY FL Verapamil hydrochloride [orb2566798]

Gallopamil hydrochloride [orb1309645]

Verapamil HCl [orb1310060]

质量保证

常用数据库链接

实验方案信息

可选规格