Verapamil HCl

SKU: orb1310060

特色

描述

Verapamil HCl is a Class IV antiarrhythmic agent that functions as a calcium channel blocker. It is widely used in cardiovascular research to study calcium signaling in vitro and to model hypertension and arrhythmia in vivo.

研究领域

Cell Biology, Neuroscience

图片与验证

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关键属性

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CAS 号	152-11-4
MW	491.06
纯度	>98%
分子式	C₂₇H₃₈N₂O₄ ∙ HCl
SMILES	Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
靶点	Ion channel
溶解性	Soluble in DMSO (up to 20 mg/ml) or in Water (up to 50 mg/ml).

生物活性

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体内	Verapamil and Diltiazem essentially inhibit the hydrolase activity of recombinant CES2, with inhibition constants (Ki) of 0.25 ± 0.02 μM and 3.84 ± 0.99 μM, respectively.
体外	Verapamil exhibits antiarrhythmic properties, reduces myocardial oxygen consumption in rats, and preserves Cx43 protein.
细胞研究	Verapamil is dissolved in DMSO and stored, and then diluted with appropriate media before use. Cells (1×105) are treated with 10 nM Bortezomib and/or 70 μM Verapamil for 16 hours and incubated for another 4 hours with Alamar-Blue. Activity of the mitochondrial dehydrogenase results in conversion of the coloring, which is followed by measurement of the absorption using a spectrophotometer.

储存与操作

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储存	RT
有效期	12 months from date of receipt.
免责声明	For research use only

别名

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(±)-Verapamil, (±)-Verapamil hydrochlorid, ABCB1, angina, antiarrhythmic, CalciumChannel, Calcium Channel, Ca2+ channels, Calcan hydrochloride, Calcan Hydrochloride, Ca channels, blood, CYP3A4, CYPs, Cytochrome P450, CD243, Cluster of differentiation 243, Palbociclib, Inhibitor, inhibit, Multidrug resistance protein 1, lysosomotropic, MDR1, Manidon, high, pressure, P-gp (P-glycoprotein), Pgp, P-gp, P-glycoprotein, Verapamil, Verapamil HCl, Verapamil hydrochlorid, Verapamil hydrochloride, Verapamil Hydrochloride

相似产品

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Lu49888 HCl [orb1696337]
CAS 号：
109293-20-1
MW:
502.06
分子式：
C₂₆H₃₆ClN₅O₃
可选规格： 100 mg, 50 mg, 25 mg
Verapamil hydrochloride [orb1226158]
纯度：
>98% (HPLC)
CAS 号：
152-11-4
MW:
491.06
分子式：
C₂₇H₃₉ClN₂O₄
可选规格： 500 mg, 1 g
Verapamil HCl [orb3066708]
可选规格： 5 g, 1 g

质量保证

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our 条款与条件和选购指南.

化合物标识

PubChem CID

62969 ↗

关键属性

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暂无计算属性。

实验方案信息

查看更多实验方案

CAS 号：	109293-20-1
MW:	502.06
分子式：	C₂₆H₃₆ClN₅O₃

纯度：	>98% (HPLC)
CAS 号：	152-11-4
MW:	491.06
分子式：	C₂₇H₃₉ClN₂O₄

Verapamil HCl

描述

研究领域

图片与验证

关键属性

生物活性

储存与操作

别名

相似产品

Lu49888 HCl [orb1696337]

Verapamil hydrochloride [orb1226158]

Verapamil HCl [orb3066708]

质量保证

化合物标识

关键属性

实验方案信息

可选规格